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Digoxin and its Toxicity

Digitalis glycoside digoxin, a category known compounds (Digitalis) and trans Verde was purified from the leaves and seeds of Digitalis and Strophanthus of foxglove (plant foxglove), the oldest drug for the treatment of patients with heart failure, the heart is still superimposed. The history of finger consumption dates back to 1500 BC, when the plant was used as a poison. For the first time in 1785, Dr. Withering explained the beneficial effects of consuming the product obtained from the flowers of the finger mud in increasing urinary excretion and treating inflammation. The ability of digitalis compounds to increase the contractile strength of the heart was recognized in the mid-19th century. Since then, many studies have been done on this drug and many scientific articles have been published about its beneficial and harmful effects. Some believe that Van Gogh saw the world more in yellow due to digoxin poisoning, and therefore used more yellow in his paintings.
It should be noted that the US Food and Drug Administration approved the use of digitalis compounds in the treatment of heart failure in 1998.